IL-6 and TNF are Potential Inflammatory Biomarkers in Facioscapulohumeral Muscular Dystrophy.

ABSTRACT:

Background

FSHD is a highly prevalent inherited myopathy with a still poorly understood pathology.

Objective

To investigate whether proinflammatory cytokines are associated with FSHD and which specific innate immune cells are involved in its pathology.

Methods

First, we measured circulating cytokines in serum samples: IL-6 (FSHD, n = 150; HC, n = 98); TNF (FSHD, n = 150; HC, n = 59); IL-1α (FSHD, n = 150; HC, n = 66); IL-1β (FSHD, n = 150; HC, n = 98); MCP-1 (FSHD, n = 14; HC, n = 14); VEGF-A (FSHD, n = 14; HC, n = 14). Second, we tested trained immunity in monocytes (FSHD, n = 15; HC, n = 15) and NK cells (FSHD, n = 11; HC, n = 11). Next, we explored the cytokine production capacity of NK cells in response to different stimuli (FSHD, n = 39; HC, n = 22). Lastly, we e

SUBMITTER: Greco A 

PROVIDER: S-EPMC10977382 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature