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Synthesis of 2-arylpyridines by the Suzuki-Miyaura cross-coupling of PyFluor with hetero(aryl) boronic acids and esters.

ABSTRACT: The Suzuki-Miyaura cross-coupling of pyridine-2-sulfonyl fluoride (PyFluor) with hetero(aryl) boronic acids and pinacol boronic esters is reported. The reactions can be performed using Pd(dppf)Cl₂ as the catalyst, at temperatures between 65 and 100 °C and in the presence of water and oxygen. This transformation generates 2-arylpyridines in modest to good yields (5%-89%).

SUBMITTER: Rueda-Espinosa J

PROVIDER: S-EPMC10978044 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Synthesis of 2-arylpyridines by the Suzuki-Miyaura cross-coupling of PyFluor with hetero(aryl) boronic acids and esters.

Rueda-Espinosa Juan J Ramanayake Dewni D Ball Nicholas D ND Love Jennifer A JA

Canadian journal of chemistry 20230830 10

The Suzuki-Miyaura cross-coupling of pyridine-2-sulfonyl fluoride (PyFluor) with hetero(aryl) boronic acids and pinacol boronic esters is reported. The reactions can be performed using Pd(dppf)Cl<sub>2</sub> as the catalyst, at temperatures between 65 and 100 °C and in the presence of water and oxygen. This transformation generates 2-arylpyridines in modest to good yields (5%-89%). ...[more]

PMID: 38550267

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