Similar immune responses to alpha1-oleate and Bacillus Calmette-Guerin treatment in patients with bladder cancer.

ABSTRACT:

Background

The molecular content of urine is defined by filtration in the kidneys and by local release from tissues lining the urinary tract. Pathological processes and different therapies change the molecular composition of urine and a variety of markers have been analyzed in patients with bladder cancer. The response to BCG immunotherapy and chemotherapy has been extensively studied and elevated urine concentrations of IL-1RA, IFN-α, IFN-γ TNF-α, and IL-17 have been associated with improved outcome.

Methods

In this study, the host response to intravesical alpha 1-oleate treatment was characterized in patients with non-muscle invasive bladder cancer by proteomic and transcriptomic analysis.

Results

Proteomic profiling detected a significant increase in multiple cytok

SUBMITTER: Ahmadi S 

PROVIDER: S-EPMC10980842 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature