Systematic review of metabolomic alterations in ulcerative colitis: unveiling key metabolic signatures and pathways.

ABSTRACT:

Background

Despite numerous metabolomic studies on ulcerative colitis (UC), the results have been highly variable, making it challenging to identify key metabolic abnormalities in UC.

Objectives

This study aims to uncover key metabolites and metabolic pathways in UC by analyzing existing metabolomics data.

Design

A systematic review.

Data sources and methods

We conducted a comprehensive search in databases (PubMed, Cochrane Library, Embase, and Web of Science) and relevant study references for metabolomic research on UC up to 28 December 2022. Significant metabolite differences between UC patients and controls were identified, followed by an analysis of relevant metabolic pathways.

Results

This review incorporated 78 studies, identifying 2868 differentia

SUBMITTER: Liu M 

PROVIDER: S-EPMC10981261 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature