Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krupple-like factor 4 deacetylation.

ABSTRACT:

Aims

Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by a high mortality rate. Pulmonary arterial endothelium cells (PAECs) serve as a primary sensor of various environmental cues, such as shear stress and hypoxia, but PAEC dysfunction may trigger vascular remodelling during the onset of PH. This study aimed to illustrate the role of Sirtuin 7 (SIRT7) in endothelial dysfunction during PH and explore the potential therapeutic strategy for PH.

Methods and results

SIRT7 levels were measured in human and murine experimental PH samples. Bioinformatic analysis, immunoprecipitation, and deacetylation assay were used to identify the association between SIRT7 and Krüpple-like factor 4 (KLF4), a key transcription factor essential for endothelial cell (EC) hom

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10981524 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature