Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages.

ABSTRACT:

Introduction

Potentiation of the bactericidal activities of leukocytes, including macrophages, upon antibacterial agent administration has been observed for several decades and is summarized as the postantibiotic leukocyte enhancement (PALE) theory. Antibiotics-induced bacterial sensitization to leukocytes is commonly recognized as the mechanism of PALE. However, the degree of sensitization drastically varies with antibiotic classes, and little is known about whether and how the potentiation of leukocytes contributes to PALE.

Objectives

In this study, we aim to develop a mechanistic understanding of PALE by investigating the immunoregulation of traditional antibiotics on macrophages.

Methods

Interaction models between bacteria and macrophages were constructed to ident

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10982861 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature