Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination.

ABSTRACT: Schwann cells are critical for the proper development and function of the peripheral nervous system, where they form a mutually beneficial relationship with axons. Past studies have highlighted that a pair of proteins called the prohibitins play major roles in Schwann cell biology. Prohibitins are ubiquitously expressed and versatile proteins. We have previously shown that while prohibitins play a crucial role in Schwann cell mitochondria for long-term myelin maintenance and axon health, they may also be present at the Schwann cell-axon interface during development. Here, we expand on this work, showing that drug-mediated modulation of prohibitins in vitro disrupts myelination and confirming that Schwann cell-specific ablation of prohibitin 2 (Phb2) in vivo results in

SUBMITTER: Wilson ER 

PROVIDER: S-EPMC10983910 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature