Reduced cell-substrate adhesion formation promotes cell migration in <i>Dictyostelium</i>.

ABSTRACT: Many cells adhere to the extracellular matrix for efficient cell migration. This adhesion is mediated by focal adhesions, a protein complex linking the extracellular matrix to the intracellular cytoskeleton. Focal adhesions have been studied extensively in Metazoan mesenchymal cells, but recent research in physiological contexts and amoeboid cells suggest that focal adhesion regulation differs from the mesenchymal focal adhesion paradigm. While focal adhesion machinery predates the origin of Metazoans, focal adhesion formation and regulation during non-Metazoan cell migration is largely unexplored. We used Dictyostelium discoideum to investigate novel mechanisms and the evolution of focal adhesion regulation, as Dictyostelium are non-Metazoans that form cell-substrate adhesio

SUBMITTER: Fierro Morales JC 

PROVIDER: S-EPMC10983970 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature