Individuals with Alzheimer's disease and low tau burden: Characteristics and implications.

ABSTRACT:

Introduction

Abnormal amyloid-beta (Aβ) and tau deposition define Alzheimer's Disease (AD), but non-elevated tau is relatively frequent in patients on the AD pathway.

Methods

We examined characteristics and regional patterns of 397 Aβ+ unimpaired and impaired individuals with low tau (A+T-) in relation to their higher tau counterparts (A+T+).

Results

Seventy-one percent of Aβ+ unimpaired and 42% of impaired Aβ+ individuals were categorized as A+T- based on global tau. In impaired individuals only, A+T- status was associated with older age, male sex, and greater cardiovascular risk. α-synuclein was linked to poorer cognition, particularly when tau was low. Tau burden was most frequently elevated in a common set of temporal regions regardless of T+/T- status.

Discuss

SUBMITTER: Landau SM 

PROVIDER: S-EPMC10984443 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature