Association of mild and complex multimorbidity with structural brain changes in older adults: A population-based study.

ABSTRACT:

Introduction

We quantified the association of mild (ie, involving one or two body systems) and complex (ie, involving ≥3 systems) multimorbidity with structural brain changes in older adults.

Methods

We included 390 dementia-free participants aged 60+ from the Swedish National Study on Aging and Care in Kungsholmen who underwent brain magnetic resonance imaging at baseline and after 3 and/or 6 years. Using linear mixed models, we estimated the association between multimorbidity and changes in total brain tissue, ventricular, hippocampal, and white matter hyperintensities volumes.

Results

Compared to non-multimorbid participants, those with complex multimorbidity showed the steepest reduction in total brain (β*time -0.03, 95% CI -0.05, -0.01) and hippocampal (β*time -0

SUBMITTER: Valletta M 

PROVIDER: S-EPMC10984455 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature