Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.

ABSTRACT:

Introduction

Associations of cerebellar atrophy with specific neuropathologies in Alzheimer's disease and related dementias (ADRD) have not been systematically analyzed. This study examined cerebellar gray matter volume across major pathological subtypes of ADRD.

Methods

Cerebellar gray matter volume was examined using voxel-based morphometry in 309 autopsy-proven ADRD cases and 80 healthy controls. ADRD subtypes included AD, mixed Lewy body disease and AD (LBD-AD), and frontotemporal lobar degeneration (FTLD). Clinical function was assessed using the Clinical Dementia Rating (CDR) scale.

Results

Distinct patterns of cerebellar atrophy were observed in all ADRD subtypes. Significant cerebellar gray matter changes appeared in the early stages of most subtypes and the v

SUBMITTER: Chen Y 

PROVIDER: S-EPMC10984510 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature