Dataset Information

Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.

ABSTRACT:

Introduction

Associations of cerebellar atrophy with specific neuropathologies in Alzheimer's disease and related dementias (ADRD) have not been systematically analyzed. This study examined cerebellar gray matter volume across major pathological subtypes of ADRD.

Methods

Cerebellar gray matter volume was examined using voxel-based morphometry in 309 autopsy-proven ADRD cases and 80 healthy controls. ADRD subtypes included AD, mixed Lewy body disease and AD (LBD-AD), and frontotemporal lobar degeneration (FTLD). Clinical function was assessed using the Clinical Dementia Rating (CDR) scale.

Results

Distinct patterns of cerebellar atrophy were observed in all ADRD subtypes. Significant cerebellar gray matter changes appeared in the early stages of most subtypes and the very early stages of AD, LBD-AD, FTLD-TDP type A, and progressive supranuclear palsy. Cortical atrophy positively predicted cerebellar atrophy across all subtypes.

Discussion

Our findings establish pathology-specific profiles of cerebellar atrophy in ADRD and propose cerebellar neuroimaging as a non-invasive biomarker for differential diagnosis and disease monitoring.

Highlights

Cerebellar atrophy was examined in 309 patients with autopsy-proven neurodegeneration. Distinct patterns of cerebellar atrophy are found in all pathological subtypes of Alzheimer's disease and related dementias (ADRD). Cerebellar atrophy is seen in early-stage (Clinical Dementia Rating [CDR] ≤1) AD, Lewy body dementia (LBD), frontotemporal lobar degeneration with tau-positive inclusion (FTLD-tau), and FTLD-transactive response DNA binding protein (FTLD-TDP). Cortical atrophy positively predicts cerebellar atrophy across all neuropathologies.

SUBMITTER: Chen Y

PROVIDER: S-EPMC10984510 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.

Chen Yu Y Spina Salvatore S Callahan Patrick P Grinberg Lea T LT Seeley William W WW Rosen Howard J HJ Kramer Joel H JH Miller Bruce L BL Rankin Katherine P KP

Alzheimer's & dementia : the journal of the Alzheimer's Association 20231218 3

<h4>Introduction</h4>Associations of cerebellar atrophy with specific neuropathologies in Alzheimer's disease and related dementias (ADRD) have not been systematically analyzed. This study examined cerebellar gray matter volume across major pathological subtypes of ADRD.<h4>Methods</h4>Cerebellar gray matter volume was examined using voxel-based morphometry in 309 autopsy-proven ADRD cases and 80 healthy controls. ADRD subtypes included AD, mixed Lewy body disease and AD (LBD-AD), and frontotemp ...[more]

PMID: 38109286

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Dataset Information

Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.

Introduction

Methods

Results

Discussion

Highlights

Publications

Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders.

Similar Datasets

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