Dataset Information
Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses.
Ontology highlight
ABSTRACT: Background
The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent vs separate administration of these vaccines remains unclear.Methods
Here, we analyzed antibody responses in health care workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or on different days through systems serology. Antibody-binding and functional responses were characterized at peak responses and after 6 months following vaccination.Results
IgG1 and neutralization responses to SARS-CoV-2 XBB.1.5 were higher at peak and after 6 months following concurrent administration as compared with separate administration of the COVID-19 and influenza vaccines. While similar results were not observed for influenza responses, no interference was noted with concurrent administration.Conclusions
These data suggest that concurrent administration of these vaccines may yield higher and more durable SARS-CoV-2 neutralizing antibody responses while maintaining responses against influenza.
SUBMITTER: Barouch SE
PROVIDER: S-EPMC10986856 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Publications
Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses.
Open forum infectious diseases 20240313 4
<h4>Background</h4>The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent vs separate administration of these vaccines remains unclear.<h4>Methods</h4>Here, we analyzed antibody responses in health care workers who received the bivalent COVID-19 booster and the influenza vaccine on the same day or on different days through systems serology. Antibody-binding and functional responses ...[more]