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Formoxyboranes as hydroborane surrogates for the catalytic reduction of carbonyls through transfer hydroboration.

ABSTRACT: A new class of Lewis base stabilized formoxyboranes demonstrates the feasibility of catalytic transfer hydroboration. In the presence of a ruthenium catalyst, they have shown broad applicability for reducing carbonyl compounds. Various borylated alcohols are obtained in high selectivity and yields up to 99%, tolerating several functional groups. Computational studies enabled to propose a mechanism for this transformation, revealing the role of the ruthenium catalyst and the absence of hydroborane intermediates.

SUBMITTER: Durin G

PROVIDER: S-EPMC10987016 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Formoxyboranes as hydroborane surrogates for the catalytic reduction of carbonyls through transfer hydroboration.

Durin Gabriel G Romero R Martin RM Godou Timothé T Chauvier Clément C Thuéry Pierre P Nicolas Emmanuel E Cantat Thibault T

Catalysis science & technology 20240216 7

A new class of Lewis base stabilized formoxyboranes demonstrates the feasibility of catalytic transfer hydroboration. In the presence of a ruthenium catalyst, they have shown broad applicability for reducing carbonyl compounds. Various borylated alcohols are obtained in high selectivity and yields up to 99%, tolerating several functional groups. Computational studies enabled to propose a mechanism for this transformation, revealing the role of the ruthenium catalyst and the absence of hydroboran ...[more]

PMID: 38571548

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