Global epistasis in plasmid-mediated antimicrobial resistance.

ABSTRACT: Antimicrobial resistance (AMR) in bacteria is a major public health threat and conjugative plasmids play a key role in the dissemination of AMR genes among bacterial pathogens. Interestingly, the association between AMR plasmids and pathogens is not random and certain associations spread successfully at a global scale. The burst of genome sequencing has increased the resolution of epidemiological programs, broadening our understanding of plasmid distribution in bacterial populations. Despite the immense value of these studies, our ability to predict future plasmid-bacteria associations remains limited. Numerous empirical studies have recently reported systematic patterns in genetic interactions that enable predictability, in a phenomenon known as global epistasis. In this perspective, we a

SUBMITTER: DelaFuente J 

PROVIDER: S-EPMC10987494 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature