Plasma biomarkers of endothelial function, inflammation and oxidative stress in individuals with non-freezing cold injury.

ABSTRACT:

New findings

What is the central question of this study? Are biomarkers of endothelial function, oxidative stress and inflammation altered by non-freezing cold injury (NFCI)? What is the main finding and its importance? Baseline plasma [interleukin-10] and [syndecan-1] were elevated in individuals with NFCI and cold-exposed control participants. Increased [endothelin-1] following thermal challenges might explain, in part, the increased pain/discomfort experienced with NFCI. Mild to moderate chronic NFCI does not appear to be associated with either oxidative stress or a pro-inflammatory state. Baseline [interleukin-10] and [syndecan-1] and post-heating [endothelin-1] are the most promising candidates for diagnosis of NFCI.

Abstract

Plasma biomarkers of inflammation, oxidative

SUBMITTER: Eglin CM 

PROVIDER: S-EPMC10988512 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature