Arylazobenzimidazoles: versatile visible-light photoswitches with tuneable <i>Z</i>-isomer stability.

ABSTRACT: Benzimidazole heterocycles are of great importance in medicinal chemistry due to their applicability to a wide range of pharmacological targets, therefore representing a prototypical "privileged structure". In photopharmacology, azoheteroarene photoswitches have emerged as valuable tools for a variety of applications due to the high tuneability of their photophysical properties. Benzimidazole-based photoswitches could therefore enable the optically-controlled investigation of many pharmacological targets and find application in materials science. Here we report a combined experimental and computational investigation of such arylazobenzimidazoles, which allowed us to identify derivatives with near-quantitative bidirectional photoswitching using visible light and highly tuneable Z-iso

SUBMITTER: Steinmuller SAM 

PROVIDER: S-EPMC10988581 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature