Toxicity and inhibition mechanism of gallic acid on physiology and fermentation performance of Escherichia coli.

ABSTRACT: Gallic acid is a natural phenolic acid that has a stress inhibition effect on Escherichia coli. This study by integrates fermentation characteristics and transcriptional analyses to elucidate the physiological mechanism of E. coli 3110 response to gallic acid. Compared with the control (without stress), the cell growth was severely retarded, and irregular cell morphology appeared in the case of high levels of gallic acid stress. The glucose consumption of E. coli was reduced successively with the increase of gallic acid content in the fermentation medium. After 20 h of gallic acid stress, cofactor levels (ATP, NAD⁺ and NADH) of E. coli 3110 were similarly decreased, indicating a more potent inhibitory effect of gallic acid on E. coli. The transcriptional analysis revealed that g

SUBMITTER: Liu L 

PROVIDER: S-EPMC10992115 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature