Dataset Information

Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review.

ABSTRACT:

Objective

Brain tumors and metastases account for approximately 10% of all status epilepticus (SE) cases. This study described the clinical characteristics, treatment, and short- and long-term outcomes of this population.

Methods

This retrospective, multi-center cohort study analyzed all brain tumor patients treated for SE at the university hospitals of Frankfurt and Marburg between 2011 and 2017.

Results

The 208 patients (mean 61.5 ± 14.7 years of age; 51% male) presented with adult-type diffuse gliomas (55.8%), metastatic entities (25.5%), intracranial extradural tumors (14.4%), or other tumors (4.3%). The radiological criteria for tumor progression were evidenced in 128 (61.5%) patients, while 57 (27.4%) were newly diagnosed with tumor at admission and 113 (54.3%) had refractory SE. The mean hospital length of stay (LOS) was 14.8 days (median 12.0, range 1-57), 171 (82.2%) patients required intensive care (mean LOS 8.9 days, median 5, range 1-46), and 44 (21.2%) were administered mechanical ventilation. All patients exhibited significant functional status decline (modified Rankin Scale) post-SE at discharge (p < 0.001). Mortality at discharge was 17.3% (n = 36), with the greatest occurring in patients with metastatic disease (26.4%, p = 0.031) and those that met the radiological criteria for tumor progression (25%, p < 0.001). Long-term mortality at one year (65.9%) was highest in those diagnosed with adult-type diffuse gliomas (68.1%) and metastatic disease (79.2%). Refractory status epilepticus cases showed lower survival rates than non-refractory SE patients (log-rank p = 0.02) and those with signs of tumor progression (log-rank p = 0.001).

Conclusions

SE occurrence contributed to a decline in functional status in all cases, regardless of tumor type, tumor progression status, and SE refractoriness, while long-term mortality was increased in those with malignant tumor entities, tumor progressions, and refractory SE. SE prevention may preserve functional status and improve survival in individuals with brain tumors.

SUBMITTER: Rickel JK

PROVIDER: S-EPMC10993483 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature

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Publications

Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review.

Rickel Johanna K JK Zeeb Daria D Knake Susanne S Urban Hans H Konczalla Jürgen J Weber Katharina J KJ Zeiner Pia S PS Pagenstecher Axel A Hattingen Elke E Kemmling André A Fokas Emmanouil E Adeberg Sebastian S Wolff Robert R Sebastian Martin M Rusch Tillmann T Ronellenfitsch Michael W MW Menzler Katja K Habermehl Lena L Möller Leona L Czabanka Marcus M Nimsky Christopher C Timmermann Lars L Grefkes Christian C Steinbach Joachim P JP Rosenow Felix F Kämppi Leena L Strzelczyk Adam A

Neurological research and practice 20240404 1

<h4>Objective</h4>Brain tumors and metastases account for approximately 10% of all status epilepticus (SE) cases. This study described the clinical characteristics, treatment, and short- and long-term outcomes of this population.<h4>Methods</h4>This retrospective, multi-center cohort study analyzed all brain tumor patients treated for SE at the university hospitals of Frankfurt and Marburg between 2011 and 2017.<h4>Results</h4>The 208 patients (mean 61.5 ± 14.7 years of age; 51% male) presented ...[more]

PMID: 38570823

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Dataset Information

Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review.

Objective

Methods

Results

Conclusions

Publications

Status epilepticus in patients with brain tumors and metastases: A multicenter cohort study of 208 patients and literature review.

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