Hyperperfusion profiles after recanalization differentially associate with outcomes in a rat ischemic stroke model.

ABSTRACT: Futile recanalization hampers prognoses of ischemic stroke after successful mechanical thrombectomy, hypothetically through post-recanalization perfusion deficits, onset-to-groin delays and sex effects. Clinically, acute multiparametric imaging studies remain challenging. We assessed possible relationships between these factors and disease outcome after experimental cerebral ischemia-reperfusion, using translational MRI, behavioral testing and multi-model inference analyses. Male and female rats (N = 60) were subjected to 45-/90-min filament-induced transient middle cerebral artery occlusion. Diffusion, T₂- and perfusion-weighted MRI at occlusion, 0.5 h and four days after recanalization, enabled tracking of tissue fate, and relative regional cerebral blood flow (rrCBF) and -vol

SUBMITTER: Franx BA 

PROVIDER: S-EPMC10993873 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature