Factors Associated With Circulating Sex Hormones in Men : Individual Participant Data Meta-analyses.

ABSTRACT:

Background

Various factors modulate circulating testosterone in men, affecting interpretation of testosterone measurements.

Purpose

To clarify factors associated with variations in sex hormone concentrations.

Data sources

Systematic literature searches (to July 2019).

Study selection

Prospective cohort studies of community-dwelling men with total testosterone measured using mass spectrometry.

Data extraction

Individual participant data (IPD) (9 studies; n = 21 074) and aggregate data (2 studies; n = 4075). Sociodemographic, lifestyle, and health factors and concentrations of total testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, and estradiol were extracted.

Data synthesis

Two-stage ra

SUBMITTER: Marriott RJ 

PROVIDER: S-EPMC10995451 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature