Immunoglobulins in COVID-19 pneumonia: from the acute phase to the recovery phase.

ABSTRACT:

Background

COVID-19 pneumonia causes hyperinflammatory response that culminates in acute respiratory syndrome (ARDS) related to increased multiorgan dysfunction and mortality risk. Antiviral-neutralizing immunoglobulins production reflect the host humoral status and illness severity, and thus, immunoglobulin (Ig) circulating levels could be evidence of COVID-19 prognosis.

Methods

The relationship among circulating immunoglobulins (IgA, IgG, IgM) and COVID-19 pneumonia was evaluated using clinical information and blood samples in a COVID-19 cohort composed by 320 individuals recruited during the acute phase and followed up to 4 to 8 weeks (n = 252) from the Spanish first to fourth waves.

Results

COVID-19 pneumonia development depended on baseline Ig concentrations. Cir

SUBMITTER: Peraire J 

PROVIDER: S-EPMC10998353 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature