Multi-omics data-based analysis characterizes molecular alterations of the vesicle genes in human colorectal cancer.

ABSTRACT: The role of vesicular genes in the development of colorectal cancer (CRC) is crucial. Analyzing alterations in these genes at multi-omics can aid in understanding the molecular pathways behind colorectal carcinogenesis and identifying potential treatment targets. However, studies on the overall alteration of vesicular genes in CRC are still lacking. In this study, we aimed to investigate the relationship between vesicle genetic alterations and CRC progression. To achieve this, we analyzed molecular alterations in CRC vesicle genes at eight levels, including mRNA, protein, and epigenetic levels. Additionally, we examined CRC overall survival-related genes that were obtained from a public database. Our analysis of chromatin structural variants, DNA methylation, chromatin accessibility, and p

SUBMITTER: Wang X 

PROVIDER: S-EPMC10998746 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature