Antithrombotic pharmacodynamics and metabolomics study in raw and processed products of Whitmania pigra Whitman.

ABSTRACT:

Objective

As a traditional Chinese medicine, leech has obvious pharmacological activities in anticoagulantion and antithrombosis. Whitmania pigra Whitman (WP) is the most commonly used leech in the Chinese market. It is often used in clinical applications after high-temperature processing by talcum powder to remove the fishy taste and facilitate crushing. The anticoagulant and thrombolytic active ingredients are protein and polypeptide, which may denaturate and lose activity after high-temperature processing. The rationality of its processing has been questioned in recent years. This study aims to investigate the effect of talcum powder scalding on the antithrombotic activity of WP in vivo and to discuss its pharmacodynamic mechanism in vivo.

Methods

Raw

SUBMITTER: Kui H 

PROVIDER: S-EPMC11002550 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature