Unknown

Dataset Information

0

Chemokine ligand 18 predicts all-cause mortality in patients hospitalized with chest pain of suspected coronary origin.


ABSTRACT:

Introduction

Chemokines mediate recruitment and activation of leucocytes. Chemokine ligand 18 (CCL18) is mainly expressed by monocytes/macrophages and dendritic cells. It is highly expressed in chronic inflammatory diseases, and locally in atherosclerotic plaques, particularly at sites of reduced stability, and systemically in acute coronary syndrome patients. Reports on its prognostic utility in the latter condition, including myocardial infarction (MI), are scarce.

Aim

To assess the utility of CCL18 as a prognostic marker of recurrent cardiovascular events in patients hospitalized with chest pain of suspected coronary origin.

Methods

The population consisted of 871 consecutive chest-pain patients, of whom 386 were diagnosed with acute myocardial infarction (AMI) based on Troponin-T (TnT) levels >50 ng/L. Stepwise Cox regression models, applying normalized continuous loge/SD values, were fitted for the biomarkers with cardiac mortality within 2 years and total mortality within 2 and 7 years as the dependent variables.

Results

Plasma samples from 849 patients were available. By 2 years follow-up, 138 (15.8%) patients had died, of which 86 were cardiac deaths. Univariate analysis showed a positive, significant association between CCL18 and total death [HR 1.55 (95% 1.30-1.83), p < 0.001], and for cardiac death [HR 1.32 (95% 1.06-1.64), p = 0.013]. Associations after adjustment were non-significant. By 7 years follow-up, 332 (38.1%) patients had died. CLL18 was independently associated with all-cause mortality [HR 1.14 (95% CI, 1.01-1.29), p = 0.030], but not with MI (n = 203) or stroke (n = 55).

Conclusion

CCL18 independently predicts long-term all-cause mortality but had no independent prognostic bearing on short-term cardiac death and CVD events.

SUBMITTER: Nilsen DWT 

PROVIDER: S-EPMC11002648 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature

altmetric image

Publications

Chemokine ligand 18 predicts all-cause mortality in patients hospitalized with chest pain of suspected coronary origin.

Nilsen Dennis W T DWT   Aarsetoey Reidun R   Poenitz Volker V   Ueland Thor T   Aukrust Pål P   Michelsen Annika E AE   Brugger-Andersen Trygve T   Staines Harry H   Grundt Heidi H  

International journal of cardiology. Cardiovascular risk and prevention 20240327


<h4>Introduction</h4>Chemokines mediate recruitment and activation of leucocytes. Chemokine ligand 18 (CCL18) is mainly expressed by monocytes/macrophages and dendritic cells. It is highly expressed in chronic inflammatory diseases, and locally in atherosclerotic plaques, particularly at sites of reduced stability, and systemically in acute coronary syndrome patients. Reports on its prognostic utility in the latter condition, including myocardial infarction (MI), are scarce.<h4>Aim</h4>To assess  ...[more]

Similar Datasets

| S-EPMC11309044 | biostudies-literature
| S-EPMC10507464 | biostudies-literature
| S-EPMC3391179 | biostudies-literature
| S-EPMC4552107 | biostudies-literature
| S-EPMC4703143 | biostudies-literature
| S-EPMC4150478 | biostudies-literature
| S-EPMC11782882 | biostudies-literature
| S-EPMC5829365 | biostudies-literature
| S-EPMC8444283 | biostudies-literature
| S-EPMC11861896 | biostudies-literature