B(C₆F₅)₃-Catalyzed Dehydrogenation of Pyrrolidines to Form Pyrroles.

ABSTRACT: Pyrroles are important N-heterocycles found in medicines and materials. The formation of pyrroles from widely accessible pyrrolidines is a potentially attractive strategy but is an underdeveloped approach due to the sensitivity of pyrroles to the oxidative conditions required to achieve such a transformation. Herein, we report a catalytic approach that employs commercially available B(C₆F₅)₃ in an operationally simple procedure that allows pyrrolidines to serve as direct synthons for pyrroles. Mechanistic studies have revealed insights into borane-catalyzed dehydrogenative processes.

SUBMITTER: Alvarez-Montoya A 

PROVIDER: S-EPMC11002826 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature