Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids.
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SUBMITTER: Blazquez-Garcia I
PROVIDER: S-EPMC11002922 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
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Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids.
Blázquez-García Irene I Guerrero Laura L Cacho-Navas Cristina C Djouder Nabil N Millan Jaime J Paradela Alberto A Carmona-Rodríguez Lorena L Corrales Fernando J FJ
Journal of proteome research 20240315 4
MDR3 (multidrug resistance 3) deficiency in humans (MDR2 in mice) causes progressive familial intrahepatic cholestasis type 3 (PFIC3). PFIC3 is a lethal disease characterized by an early onset of intrahepatic cholestasis progressing to liver cirrhosis, a preneoplastic condition, putting individuals at risk of hepatocellular carcinoma (HCC). Hepatocyte-like organoids from MDR2-deficient mice (MDR2KO) were used in this work to study the molecular alterations caused by the deficiency of this transp ...[more]
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