Approaches to optimize analyses of multidimensional ordinal MRI data in osteoarthritis research: A perspective.

ABSTRACT:

Objective

Knee osteoarthritis (OA) is a disease of the whole joint involving multiple tissue types. MRI-based semi-quantitative (SQ) scoring of knee OA is a method to perform multi-tissue joint assessment and has been shown to be a valid and reliable way to measure structural multi-tissue involvement and progression of the disease. While recent work has described how SQ scoring may be used for clinical trial enrichment and disease phenotyping in OA, less guidance is available for how these parameters may be used to assess study outcomes.

Design

Here we present recommendations for summarizing disease progression within specific tissue types. We illustrate how various methods may be used to quantify longitudinal change using SQ scoring and review examples from the literature.<

SUBMITTER: Collins JE 

PROVIDER: S-EPMC11004399 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature