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Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study.

ABSTRACT:

Objective

This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort.

Methods

From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI.

Results

The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84-0.97) in the dementia group. According to the subgroup analysis, the adjusted OR for HZI was 0.91 (95% confidence interval [CI] = 0.83 -1.00) in the < 80 years old group, 0.88 (95% CI = 0.78 -1.00) in the ≥ 80 years old group, 0.77 (95% CI = 0.66-0.89) in men and 0.96 (95% CI = 0.88 -1.05) in women.

Conclusions

We concluded that HZI does not increase the risk of neurodegenerative dementia in individuals of any age or of either sex.

SUBMITTER: Choi HG

PROVIDER: S-EPMC11005322 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature

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Herpes Zoster Does Not Increase the Risk of Neurodegenerative Dementia: A Case-Control Study.

Choi Hyo Geun HG Park Bum Jung BJ Lim Jae Sung JS Sim Song Yong SY Jung Yoon Jung YJ Lee Suk Woo SW

American journal of Alzheimer's disease and other dementias 20210101

<h4>Objective</h4>This study was conducted to evaluate the association between neurodegenerative dementia and herpes zoster infection (HZI) using a national sample cohort.<h4>Methods</h4>From the national cohort study conducted by the Korean National Health Insurance Service, we extracted data for patients with neurodegenerative dementia and for 1:4 matched control participants and searched the patient histories for HZI.<h4>Results</h4>The adjusted odds ratio (OR) for HZI was 0.90 (95% CI = 0.84 ...[more]

PMID: 33882722

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