Molecular characterization of Golgi apparatus-related genes indicates prognosis and immune infiltration in osteosarcoma.

ABSTRACT:

Background

The Golgi apparatus (GA) is crucial for protein synthesis and modification, and regulates various cellular processes. Dysregulation of GA can lead to pathological conditions like neoplastic growth. GA-related genes (GARGs) mutations are commonly found in cancer, contributing to tumor metastasis. However, the expression and prognostic significance of GARGs in osteosarcoma are yet to be understood.

Methods

Gene expression and clinical data of osteosarcoma patients were obtained from the TARGET and GEO databases. A consensus clustering analysis identified distinct molecular subtypes based on GARGs. Discrepancies in biological processes and immunological features among the subtypes were explored using GSVA, ssGSEA, and Metascape analysis. A GARGs signature was constru

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11006476 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature