Markers of intestinal barrier damage in patients with chronic insomnia disorder.

ABSTRACT:

Objective

Insomnia disorder stands out as one of the prevalent clinical sleep and psychiatric disorders. Prior research has unequivocally demonstrated variations in the diversity and abundance of gut microbiota among individuals with insomnia disorder. These alterations may play a direct or indirect role in the onset and progression of insomnia disorder by compromising the integrity of the intestinal barrier. This study aims to evaluate the impairment of the intestinal barrier in individuals with insomnia disorder by scrutinizing the serum functionality of this barrier.

Materials and methods

45 patients with chronic insomnia disorder and 30 matched healthy volunteers were meticulously selected based on inclusion criteria. ELISA technology was employed to measure serum levels

SUBMITTER: Cai Y 

PROVIDER: S-EPMC11007705 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature