Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors.

ABSTRACT:

Background

Major depressive disorder (MDD) has been identified as a causal risk factor for multiple forms of cardiovascular disease. Although observational evidence has linked MDD to peripheral artery disease (PAD), causal evidence of this relationship is lacking.

Methods and results

Inverse variance weighted 2-sample Mendelian randomization was used to test the association the between genetic liability for MDD and genetic liability for PAD. Genetic liability for MDD was associated with increased genetic liability for PAD (odds ratio [OR], 1.17 [95% CI, 1.06-1.29]; P=2.6×10^-3). Genetic liability for MDD was also associated with increased genetically determined lifetime smoking (β=0.11 [95% CI, 0.078-0.14]; P=1.2×10^-12), decreased al

SUBMITTER: Shakt G 

PROVIDER: S-EPMC11010076 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature