Longitudinal enlargement of choroid plexus is associated with chronic lesion expansion and neurodegeneration in RRMS patients.

ABSTRACT:

Background and objective

We explored dynamic changes in the choroid plexus (CP) in patients with relapsing-remitting multiple sclerosis (RRMS) and assessed its relationship with chronic lesion expansion and atrophy in various brain compartments.

Methods

Fifty-seven RRMS patients were annually assessed for a minimum of 48 months with 3D FLAIR, pre- and post-contrast 3D T1 and diffusion-weighted magnetic resonance imaging (MRI). The CP was manually segmented at baseline and last follow-up.

Results

The volume of CP significantly increased by 1.4% annually. However, the extent of CP enlargement varied considerably among individuals (ranging from -3.6 to 150.8 mm³ or -0.2% to 6.3%). The magnitude of CP enlargement significantly correlated with central (r

SUBMITTER: Klistorner S 

PROVIDER: S-EPMC11010552 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature