Endothelial and inflammatory pathophysiology in dengue shock: New insights from a prospective cohort study in Vietnam.

ABSTRACT: Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid). Plasm

SUBMITTER: McBride A 

PROVIDER: S-EPMC11020502 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature