Endothelial Nitric Oxide Pathways in the Pathophysiology of Dengue: A Prospective Observational Study.

ABSTRACT:

Background

Dengue can cause increased vascular permeability that may lead to hypovolemic shock. Endothelial dysfunction may underlie this; however, the association of endothelial nitric oxide (NO) pathways with disease severity is unknown.

Methods

We performed a prospective observational study in 2 Vietnamese hospitals, assessing patients presenting early (<72 hours of fever) and patients hospitalized with warning signs or severe dengue. The reactive hyperemic index (RHI), which measures endothelium-dependent vasodilation and is a surrogate marker of endothelial function and NO bioavailability, was evaluated using peripheral artery tonometry (EndoPAT), and plasma levels of l-arginine, arginase-1, and asymmetric dimethylarginine were measured at serial time-points. The main o

SUBMITTER: Yacoub S 

PROVIDER: S-EPMC5850435 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature