Coupled scRNA-seq and Bulk-seq reveal the role of HMMR in hepatocellular carcinoma.

ABSTRACT:

Background

Hyaluronan-mediated motility receptor (HMMR) is overexpressed in multiple carcinomas and influences the development and treatment of several cancers. However, its role in hepatocellular carcinoma (HCC) remains unclear.

Methods

The "limma" and "GSVA" packages in R were used to perform differential expression analysis and to assess the activity of signalling pathways, respectively. InferCNV was used to infer copy number variation (CNV) for each hepatocyte and "CellChat" was used to analyse intercellular communication networks. Recursive partitioning analysis (RPA) was used to re-stage HCC patients. The IC₅₀ values of various drugs were evaluated using the "pRRophetic" package. In addition, quantitative reverse transcription polymerase chain reaction (qRT-

SUBMITTER: Su Z 

PROVIDER: S-EPMC11021596 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature