Analysis of cuproptosis-related genes in prognosis and immune infiltration in grade 4 diffuse gliomas.

ABSTRACT:

Background

Grade 4 diffuse gliomas are highly malignant tumours with poor prognosis. Cuproptosis is a novel form of cell death. Cuproptosis genes are associated with various tumours and affect the prognosis of patients with these tumours. However, the relationship between cuproptosis and grade 4 diffuse gliomas remains unclear.

Methods

Differentially expressed genes associated with cuproptosis in grade 4 diffuse gliomas were identified. Second, the prognostic model was established by univariate and multivariate COX regression analyses, and the genes (p < 0.05) were selected for subsequent analysis. The endpoint of the study was death. Single-gene analysis was performed in accordance with the expression levels of SLC31A1. Third, based on the expression levels of SLC31A1, gene

SUBMITTER: Liu H 

PROVIDER: S-EPMC11021980 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature