Effects of PDE-3 inhibition in persistent post-traumatic headache: evidence of cAMP-dependent signaling.

ABSTRACT:

Background

Phosphodiesterase 3 (PDE-3) inhibition have been implicated in the neurobiologic underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH), we aimed to ascertain whether PDE-3 inhibition can elicit migraine-like headache in persons with PPTH.

Methods

We tested cilostazol, which inhibits PDE-3, in a randomized, double-blind, placebo-controlled, two-way crossover study involving persons with PPTH attributed to mild traumatic brain injury. The randomized participants were allocated to receive oral administration of either 200-mg cilostazol or placebo (calcium tablet) on two separate experiment days. The primary end point was the incidence of migraine-like headache during a 12-hour observation windo

SUBMITTER: Al-Khazali HM 

PROVIDER: S-EPMC11022386 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature