A conformal TOF-DOI Prism-PET prototype scanner for high-resolution quantitative neuroimaging.

ABSTRACT:

Background

Positron emission tomography (PET) has had a transformative impact on oncological and neurological applications. However, still much of PET's potential remains untapped with limitations primarily driven by low spatial resolution, which severely hampers accurate quantitative PET imaging via the partial volume effect (PVE).

Purpose

We present experimental results of a practical and cost-effective ultra-high resolution brain-dedicated PET scanner, using our depth-encoding Prism-PET detectors arranged along a compact and conformal gantry, showing substantial reduction in PVE and accurate radiotracer uptake quantification in small regions.

Methods

The decagon-shaped prototype scanner has a long diameter of 38.5 cm, a short diameter of 29.1 cm, and an axial field

SUBMITTER: Zeng X 

PROVIDER: S-EPMC11025680 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature