Tumor-associated macrophages expressing galectin-9 identify immunoevasive subtype muscle-invasive bladder cancer with poor prognosis but favorable adjuvant chemotherapeutic response.

ABSTRACT:

Purpose

Tumor-associated macrophages (TAMs) exist as heterogeneous subsets and have dichotomous roles in cancer-immune evasion. This study aims to assess the clinical effects of Galectin-9⁺ tumor-associated macrophages (Gal-9⁺TAMs) in muscle-invasive bladder cancer (MIBC).

Experimental design

We identified Gal-9⁺TAMs by immunohistochemistry (IHC) analysis of a tumor microarray (TMA) (n = 141) from the Zhongshan Hospital and by flow cytometric analysis of tumor specimens (n = 20) from the Shanghai Cancer Center. The survival benefit of platinum-based chemotherapy in this subpopulation was evaluated. The effect of the tumor-immune microenvironment with different percentages of Gal-9⁺TAMs was explored.

Results

The frequency of

SUBMITTER: Qi Y 

PROVIDER: S-EPMC11028176 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature