Prevotella intermedia boosts OSCC progression through ISG15 upregulation: a new target for intervention.

ABSTRACT:

Purpose

Periodontitis-associated bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, are closely linked to the risk of oral squamous cell carcinoma (OSCC). Emerging studies have indicated that another common periodontal pathogen, Prevotella intermedia (P. intermedia), is enriched in OSCC and could affect the occurrence and progression of OSCC. Our aim is to determine the effects of P. intermedia on the progression of OSCC and the role of antibiotics in reversing these effects.

Methods

In this study, a murine xenograft model of OSCC was established, and the mice were injected intratumorally with PBS (control group), P. intermedia (P.i group), or P. intermedia combined with an antibiotic cocktail administration (P.i + ABX group), respectively. The effects o

SUBMITTER: Qin Y 

PROVIDER: S-EPMC11033248 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature