Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.
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ABSTRACT:
SUBMITTER: Kirkwood CD
PROVIDER: S-EPMC110359 | biostudies-literature | 1998 Nov
REPOSITORIES: biostudies-literature
Publications
Attachment and growth of human rotaviruses RV-3 and S12/85 in Caco-2 cells depend on VP4.
Kirkwood C D CD Bishop R F RF Coulson B S BS
Journal of virology 19981101 11
Studies with human neonatal rotaviruses RV-3 and S12/85 and their reassortants showed that VP4 is a determinant of rotavirus attachment to and growth in Caco-2 cells. The binding of these viruses to MA104 and Caco-2 cells correlated with their growth ability. Virus sensitivity to trypsin and the VP4 fusion region may be implicated in these processes. ...[more]
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