Diagnosis of thoracic SMARCA4-deficient undifferentiated tumor in cytology.

ABSTRACT:

Introduction

Although alterations in SMARCA4-deficient occur in non-small cell lung carcinoma (SD-NSCLC), thoracic SMARCA4-deficient undifferentiated tumor (TSDUT) is recognized as a distinct entity in the 2021 World Health Organization Classification of Thoracic Tumors because of unique morphologic, immunophenotypic and molecular features, and worse survival compared with SD-NSCLC. Cytologic diagnosis of TSDUT is clinically important because of its aggressive behavior and because it is often diagnosed by fine-needle aspiration because TSDUTs are usually unresectable at presentation. Here, we identify cytologic features that can be used for recognition of TSDUT and distinction from SD-NSCLC.

Materials and methods

Cytomorphologic features were investigated in cytology specime

SUBMITTER: Kezlarian B 

PROVIDER: S-EPMC11037264 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature