Impaired metabolic flexibility to fasting is associated with increased ad libitum energy intake in healthy adults.

ABSTRACT:

Objective

We investigated how changes in 24-h respiratory exchange ratio (RER) and substrate oxidation during fasting versus an energy balance condition influence subsequent ad libitum food intake.

Methods

Forty-four healthy, weight-stable volunteers (30 male and 14 female; mean [SD], age 39.3 [11.0] years; BMI 31.7 [8.3] kg/m²) underwent 24-h energy expenditure measurements in a respiratory chamber during energy balance (50% carbohydrate, 30% fat, and 20% protein) and 24-h fasting. Immediately after each chamber stay, participants were allowed 24-h ad libitum food intake from computerized vending machines.

Results

Twenty-four-hour RER decreased by 9.4% (95% CI: -10.4% to -8.5%; p < 0.0001) during fasting compared to energy balance, reflecting a decrease in

SUBMITTER: Unlu Y 

PROVIDER: S-EPMC11045162 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature