The probability of chromatin to be at the nuclear lamina has no systematic effect on its transcription level in fruit flies.

ABSTRACT:

Background

Multiple studies have demonstrated a negative correlation between gene expression and positioning of genes at the nuclear envelope (NE) lined by nuclear lamina, but the exact relationship remains unclear, especially in light of the highly stochastic, transient nature of the gene association with the NE.

Results

In this paper, we ask whether there is a causal, systematic, genome-wide relationship between the expression levels of the groups of genes in topologically associating domains (TADs) of Drosophila nuclei and the probabilities of TADs to be found at the NE. To investigate the nature of this possible relationship, we combine a coarse-grained dynamic model of the entire Drosophila nucleus with genome-wide gene expression data; we analyze the TAD averaged trans

SUBMITTER: Afanasyev AY 

PROVIDER: S-EPMC11071202 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature