Genome-wide distribution of 5-hydroxymethyluracil and chromatin accessibility in the Breviolum minutum genome.

ABSTRACT:

Background

In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystalline chromosomes, primarily packaged by proteins other than histones, genes organized in very long unidirectional gene arrays, a general absence of transcriptional regulation, high abundance of the otherwise very rare DNA modification 5-hydroxymethyluracil (5-hmU), and many others. While most of these fascinating properties are originally identified in the 1970s and 1980s, they have not yet been investigated using modern genomic tools.

Results

In this work, we address some of the outstanding questions regarding dinoflagellate genome organization by mapping the

SUBMITTER: Marinov GK 

PROVIDER: S-EPMC11071213 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature