Breakpoint regions of an RHD-CE(4-9)-D allele and a rare JK allele in a Pacific Islander individual.

ABSTRACT:

Background

Among 710 RHD alleles, 3 alleles have been shown to express CcEe antigens and, among 67 hybrid alleles of the RHD gene, 2 alleles have evolved to include RHCE exons 4-9. No breakpoint region had been described for such RHD-CE(4-9)-D hybrid alleles. In the Kidd blood group system, the JK*02N.01 null allele is found with high prevalence in the Polynesian population. We investigated a self-identified Pacific Islander with discrepant serologic and molecular results for his C and Jk^b antigens. Another 8 samples with genotype-phenotype discrepancies in the Kidd blood group system were assessed.

Materials and methods

A combination of published molecular methods and commercial kits were applied to analyze the RHD, RHCE, and SLC14A1 gene sequences, as were hemag

SUBMITTER: Srivastava K 

PROVIDER: S-EPMC11073622 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature