Impact of liver fibrosis on COVID-19 in-hospital mortality in Southern Italy.

ABSTRACT:

Background & aims

SARS-Cov-2 infection manifests as a wide spectrum of clinical presentation and even now, despite the global spread of the vaccine, contagiousness is still elevated. The aim of the study was the evaluation of the impact of liver fibrosis assessed by FIB-4 and liver impairment, assessed by cytolysis indices, on intrahospital mortality in COVID-19 subjects.

Methods

This is a retrospective observational cohort study, which involved 23 COVID Hospital Units in Campania Region, Italy. Exposure variables were collected during hospital admission and at discharge. According to FIB-4 values, we subdivided the overall population in three groups (FIB-4<1.45; 1.453.25), respectively group 1,2,3.

Results

At the end of the study, 938 individuals h

SUBMITTER: Galiero R 

PROVIDER: S-EPMC11075870 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature