Effect of bile reflux on gastric juice microbiota in patients with different histology phenotypes.

ABSTRACT:

Background/aims

Bile reflux (BR) can influence the gastric environment by altering gastric acidity and possibly the gastric microbiota composition. This study investigated the correlation between bile acids and microbial compositions in the gastric juice of 50 subjects with differing gastric pathologies.

Methods

This study included 50 subjects, which were categorized into three groups based on the endoscopic BR grading system. The primary and secondary bile acid concentrations in gastric juice samples were measured, and microbiota profiling was conducted using 16 S rRNA gene sequencing.

Results

Significant differences were observed in each bile acid level in the three endoscopic BR groups (P < 0.05). The Shannon index demonstrated a significant decrease in the higher

SUBMITTER: Kim YS 

PROVIDER: S-EPMC11077708 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature