CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation.

ABSTRACT:

Background

Tetraspanin CD151 is highly expressed in endothelia and reinforces cell adhesion, but its role in vascular inflammation remains largely unknown.

Methods

In vitro molecular and cellular biological analyses on genetically modified endothelial cells, in vivo vascular biological analyses on genetically engineered mouse models, and in silico systems biology and bioinformatics analyses on CD151-related events.

Results

Endothelial ablation of Cd151 leads to pulmonary and cardiac inflammation, severe sepsis, and perilous COVID-19, and endothelial CD151 becomes downregulated in inflammation. Mechanistically, CD151 restrains endothelial release of proinflammatory molecules for less leukocyte infiltration. At the subcellular level, CD151 determines the integrit

SUBMITTER: Chen J 

PROVIDER: S-EPMC11081830 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature