Exosomes Derived from Mouse Breast Carcinoma Cells Facilitate Diabetic Wound Healing.

ABSTRACT:

Background

Exosomes derived from breast cancer have been reported to play a role in promoting cell proliferation, migration, and angiogenesis, which has the potential to accelerate the healing process of diabetic wounds. The aim of this investigation was to examine the function of exosomes originating from 4T1 mouse breast carcinoma cells (TEXs) in the process of diabetic wound healing.

Methods

The assessment of primary mouse skin fibroblasts cell proliferation and migration was conducted through the utilization of CCK-8 and wound healing assays, while the tube formation of HUVECs was evaluated by tube formation assay. High-throughput sequencing, RT-qPCR and cell experiments were used to detect the roles of miR-126a-3p in HUVECs functions in vitro. The in vivo study employed

SUBMITTER: Zhang C 

PROVIDER: S-EPMC11087414 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature